Limited proteolysis of myoglobin opens channel in ferrochelatase-globin complex for iron to zinc transmetallation
نویسندگان
چکیده
منابع مشابه
Structural determinants of limited proteolysis.
Limited or regulatory proteolysis plays a critical role in many important biological pathways like blood coagulation, cell proliferation, and apoptosis. A better understanding of mechanisms that control this process is required for discovering new proteolytic events and for developing inhibitors with potential therapeutic value. Two features that determine the susceptibility of peptide bonds to...
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Degradation pathways of insoluble proteins have been analyzed in Escherichia coli by using a N-terminal beta-galactosidase fusion protein (VP1LAC) that aggregates immediately after its synthesis. In recombinant E. coli cells, lower molecular mass products, antigenically related to the entire fusion, accumulate together with the entire fusion. In absence of protein synthesis, the insoluble intac...
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The coordinated iron structure and ferrochelatase binding surface of human frataxin have been characterized to provide insight into the protein's ability to serve as the iron chaperone during heme biosynthesis.
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15 صفحه اولProtein kinase CK2 opens the gate for zinc signaling
The importance of zinc in biology is evidenced by the growing number of disease states that directly involve aberrant levels of zinc, including neurodegeneration, inflammation, diabetes, cancer and more. Zinc is a component of an estimated 10% of all proteins and has a well-established role in regulation of gene expression, primarily through activation of metalresponsive transcription factor-1 ...
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ژورنال
عنوان ژورنال: Food Chemistry
سال: 2016
ISSN: 0308-8146
DOI: 10.1016/j.foodchem.2016.04.109